Synergistic enhancement in voltammetric detection of L-Tyrosine using a glassy carbon electrode modified with the composite of graphene oxide, graphitic carbon nitride, and zinc oxideSandeep R. Kurundawade and Sharanappa T. Nandibewoor Department of Chemistry, School of Advanced Sciences, KLE Technological University, Hubballi, India
E-mail: stnandibewoor@yahoo.com Received: 7 April 2025 Accepted: 6 September 2025 Abstract: A novel and sensitive electrochemical sensor was developed for the detection of L-Tyrosine (LTRS), utilizing a composite of Graphene Oxide, Graphitic Carbon Nitride, and Zinc Oxide to functionalize a Glassy Carbon Electrode (GCE). The modified GCE exhibited significantly enhanced electrochemical activity for L-Tyrosine, attributed to the increased surface area and electrocatalytic properties provided by the modifier. The electrode modifier was characterized using XRD and SEM–EDS techniques. Cyclic voltammetry (CV) and square wave voltammetry (SWV) were employed to investigate LTRS detection. Optimal LTRS oxidation occurred for the pH of 5.0, and the reaction was identified as irreversible and diffusion-controlled. This method enables the highly sensitive electrochemical detection of LTRS. Under optimized experimental conditions, the oxidation peak current of LTRS was directly proportional to its concentration in the range of 1.0–10 µM, with a detection limit (LOD) of 20.07 nM. The method was successfully applied to measure LTRS in pharmaceutical products, demonstrating satisfactory recovery, stability, and sensitivity. A probable electro-oxidation mechanism was proposed. These results indicate that the developed sensor could be valuable for pharmacokinetic studies and quality control laboratories. Keywords: L-Tyrosine; Glassy carbon electrode; Graphene oxide; Zinc oxide; Electrochemical sensor; Voltammetry Full paper is available at www.springerlink.com. DOI: 10.1007/s11696-025-04368-y
Chemical Papers 79 (12) 9025–9036 (2025) |
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