ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

A bimetallic yttrium-zinc-based metal−organic framework as an efficient platform for voltammetric sensing epinephrine in the presence of acetaminophen

Shamsi Esmaeelzadeh, Niloufar Akbarzadeh-T, Somayeh Tajik, and Hadi Beitollahi

Department of Chemistry, University of Sistan and Baluchestan, Zahedan, Iran

E-mail: n.akbarzadeh@chem.usb.ac.ir

Received: 13 March 2025  Accepted: 17 May 2025

Abstract:

Determination of pharmaceutical compounds and biological species in real samples is of significant importance and has been widely considered in recent years. In this work, a voltammetric sensor has been designed for detecting epinephrine (EP). This sensor utilizes a bimetallic yttrium-zinc metal–organic framework (Y-Zn-MOF) to modify a carbon paste electrode (Y-Zn-MOFs/CPE), aiming to enhance the charge transfer rate. The electrocatalytic performance of the Y-Zn-MOFs/CPE sensor was analyzed using cyclic voltammetry, revealing improved performance compared to the unmodified electrode. The Y-Zn-MOFs significantly enhance the electrocatalytic activity toward EP. The Y-Zn-MOFs/CPE sensor exhibited a wide linear dynamic range from 0.01 to 700.0 µM, with low limit of detection of 0.003 µM for EP. Moreover, differential pulse voltammetry results indicated that the peak-to-peak separation for EP and acetaminophen (AC) was 170 mV at the Y-Zn-MOFs/CPE. This suggests that the proposed electrode can simultaneously and selectively detect both compounds. It can also be utilized for detecting EP and AC in real specimens, achieving a recovery of 96.7–103.3%. This demonstrates a promising application potential for the electrochemical detection of EP and AC detection.

Keywords: Biomethanol; Coordination Polymer; Electrochemistry; Electrocatalysis; Materials for Energy and Catalysis; Metal-organic Frameworks; Voltammetric sensor; Modified electrode; Metal–organic frameworks; Epinephrine; Acetaminophen

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-025-04137-x

Chemical Papers 79 (8) 5439–5449 (2025)