ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

A decade of advances in the synthesis and biological potential of 1,2,3-triazolines

Yasmine Rahma Hachemi and Mohammed Hamadouche

Laboratoire de Chimie Fine, Département de Chimie, Faculté Des Sciences Exactes Et Appliquées, Université Oran1 Ahmed Ben Bella, Oran, Algérie

E-mail: hachemi.yasmine@univ-oran1.dz

Received: 15 March 2025  Accepted: 9 September 2025

Abstract:

Nitrogen-containing heterocycles are crucial in agrochemicals, material science, pharmaceuticals, and biologicals process, making them a major focus of research and development. The present review outlines recent methods for the synthesis of 1,2,3-triazolines through cycloaddition and their different properties published over the past decade. The supplied data demonstrate the various routes to synthesize 1,2,3-triazolines core such as 1,3-dipolar cycloaddition of azide/alkene or diazo group compound/Schiff base. This highlights the vast potential of these heterocycles derivatives for the design of potent bioactive molecules.

Graphical abstract

Keywords: 1,2,3-triazolines; Organic azides; Alkenes; Diazoalkanes; Schiff bases; Bioactive molecules

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-025-04379-9

Chemical Papers 79 (12) 8281–8300 (2025)