ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Electrochemical preparation and the characterizations of poly(3,5-diamino 1,2,4-triazole) film for the selective determination of pyridoxine in pharmaceutical formulations

Santhy Antherjanam and Beena Saraswathyamma

Department of Chemistry, Amrita Vishwa Vidyapeetham, Amritapuri, Kollam, India

E-mail: beenas@am.amrita.edu

Received: 18 October 2022  Accepted: 10 March 2023

Abstract:

This work describes the synthesis and characterization of a polymeric film of 3,5-diamino 1,2,4-triazole on a pencil graphite electrode for the selective sensing of pyridoxine (PY). The PGE was modified using the electropolymerization process by the potentiodynamic method. The polymerized electrode (PDAT/PGE) was characterized by IR, SEM, AFM, cyclic voltammetry, and electrochemical impedance spectroscopy. PY undergoes irreversible oxidation at 0.79 V on PDAT/PGE in phosphate buffer of pH 5. Using the differential pulse voltammetric technique (DPV), PY showed a linear range from 5 to 950 μM with a lower detection limit of 2.96 μM. The PDAT/PGE was applied for the analytical determination of PY in pharmaceutical tablets with good recovery.

Graphical abstract

Keywords: Pyridoxine; Voltammetry; 3,5-diamino 1,2,4-triazole

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-023-02777-5

Chemical Papers 77 (8) 4285–4296 (2023)