ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Synthesis and membrane-protective properties of aminomethyl derivatives of quercetin at the C-8 position

Evgeny V. Buravlev, Oksana G. Shevchenko, Irina Y. Chukicheva, and Alexandr V. Kutchin

Ural Branch of the Russian Academy of Sciences, Syktyvkar, Russian Federation

E-mail: eugeneburavlev@gmail.com

Abstract: A set of four C-8-aminomethyl derivatives of quercetin has been synthesized by Mannich reaction. The synthesis was carried out using a simple procedure to give target compounds as hydrochlorides. Study of oxidative hemolysis on mice erythrocytes showed that derivatives with morpholinomethyl or thiomorpholinomethyl groups favorably differ from the original quercetin by the ability to protect cells from acute oxidative stress.

Keywords: Quercetin ; Aminomethylation ; Mannich reaction ; Membrane-protective activity ; Oxidative hemolysis ; Antioxidant 

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-017-0272-y

Chemical Papers 72 (1) 201–208 (2018)