ISSN print edition: 0366-6352
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Synthesis of aspirin-ligated cisplatin derivatives and its slow release study over MIL-101(Fe)

Venansia Avelia Rosari, Witri Wahyu Lestari, and Maulidan Firdaus

Magister of Chemistry Programme, Universitas Sebelas Maret, Surakarta, Indonesia



Received: 8 August 2019  Accepted: 19 February 2020


An aspirin-ligated cisplatin derivative, biasplatin, was prepared from acetylsalicylic anhydride and oxoplatin in DMF. Biasplatin was synthesized from oxoplatin and aspirin anhydride as starting materials by a substitution reaction of hydroxo leaving groups in its axial position. The obtained biasplatin was fully characterized by FTIR, 1HNMR, 13CNMR, and ESI mass spectroscopy. Biasplatin entrapped into MIL-101(Fe) by suspended in DMF and stirring for 72 h at ambient temperature, known as biasplatin@MIL-101(Fe). The slow release of biasplatin and biasplatin@MIL-101(Fe) was conducted in PBS solution pH 7.20, 37 °C as media and measured by UV–Vis spectrophotometer. The release of biasplatin without loaded into MIL-101(Fe) is persistent for 3%, and biasplatin@MIL-101(Fe) is 0.05% over 72 h. A significant slow release of biasplatin@MIL-101(Fe) only 1% compared with time release of biasplatin without loaded into MIL-101(Fe).

Keywords: Cisplatin derivatives; Biasplatin; Aspirin; MIL-101(Fe); Time release

Full paper is available at

DOI: 10.1007/s11696-020-01114-4


Chemical Papers 74 (8) 2733–2741 (2020)

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