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A carbazole-based fluorescent probe for ultra-fast detection of ClO and its application to live cell imaging

Jianbin Chao, Yuexiang Duan, Yongbin Zhang, Fangjun Huo, Caixia Yin, Miao Xu, and Ming Li

Scientific Instrument Center, Shanxi University, Taiyuan, People’s Republic of China

 

E-mail: chao@sxu.edu.cn

Received: 24 July 2019  Accepted: 11 October 2019

Abstract:

A new fluorescent probe, (E)-3-(9-ethyl-9H-carbazol-6-yl)-1-(2-hydroxy-5-methoxyphenyl)prop-2-en-1-one (Probe 1), was synthesized based on the carbazole fluorophore for detecting ClO. The fluorescent probe exhibited specificity for ClO in many analytes and excellent anti-interference ability during detection. In addition, the fluorescence intensity at 525 nm illustrated a good linear relationship with the concentration of ClO in the range of 53.6–107.2 μM and the limit of detection was 0.30 μM. Furthermore, fluorescence imaging results confirmed that Probe 1 can be applied to monitor ClO in HepG2 cells, which indicated that Probe 1 has large potential for monitoring ClO in vivo.

Keywords: Fluorescence intensity; Carbazole; ClO−; Imaging

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-019-00958-9

 

Chemical Papers 74 (4) 1171–1176 (2020)

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