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Development of silver nanoparticles-loaded CMC hydrogel using bamboo as a raw material for special medical applications

Harish Kumar, Ankur Gaur, Sushil Kumar, and Jin-Won Park

Motilal Nehru National Institute of Technology, Allahabad, India



Abstract: The present investigation focuses on the synthesis of silver nanoparticles (Ag-NPs)-loaded hydrogel from synthetic and lab-made carboxymethyl cellulose (CMC) using bamboo as a raw material. The Ag-NPs were made by in situ process by the reaction of CMC and epichlorohydrin in alkaline medium containing silver nitrate. CMC acts as a stabilizer and reducing agent in the formation of nanoparticles. The formation of Ag-NPs was confirmed by UV–Vis spectrophotometer, as an absorption peak around 425 nm was observed. The Ag-NPs antibacterial activity against Escherichia coli (ATCC 433), Bacillus subtilis (ATCC 1688) was calculated by agar disk diffusion technique method. The characterization of the Ag-NPs was done by FTIR, SEM, TEM, particle size analyzer and EDX. Ag-NPs obtained from lab-made CMC displayed a higher antibacterial action towards Gram-negative (Escherichia coli) bacteria as well as Gram-Positive bacteria (Bacillus subtilis) as compared to synthetic CMC obtained from market.

Keywords: Carboxymethyl cellulose ; Silver nanoparticles (Ag-NPs) ; Silver nitrate ; Antibacterial activity ; Hydrogel 

Full paper is available at

DOI: 10.1007/s11696-018-0650-0


Chemical Papers 73 (4) 953–964 (2019)

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