ISSN print edition: 0366-6352
ISSN electronic edition: 1336-9075
Registr. No.: MK SR 9/7
FeCl2·4H2O catalyzed ritter reaction with nitriles and halohydrocarbons
Cheng-Liang Feng, Gui-Bo Yin, Bin Yan, Jun-Qing Chen, and Min Ji
Jiangsu College of Engineering and Technology, Nantong, People’s Republic of China
Abstract: An efficient and inexpensive synthesis of N-substituted amides from the Ritter reaction of nitriles with various halohydrocarbons catalyzed by FeCl2·4H2O is described. FeCl2·4H2O economically efficiently catalyzed the Ritter reaction under solvent-free conditions. A range of halohydrocarbons (benzyl, tert-butyl and sec-alkyl halohydrocarbons) were coupled with nitriles to provide the corresponding amides in high to excellent yields.
Keywords: FeCl2·4H2O ; Amides ; Nitriles ; Halohydrocarbons ; Ritter reaction
Full paper is available at www.springerlink.com.
Chemical Papers 73 (2) 345–353 (2019)
Friday, December 08, 2023