ISSN print edition: 0366-6352
ISSN electronic edition: 1336-9075
Registr. No.: MK SR 9/7
Kinetic study on extractive resolution of tropic acid by hydroxyethyl-β-cyclodextrin
Weifeng Xu, Pan Jiang, Kewen Tang, Panliang Zhang, and Biquan Xiong
Hunan Institute of Science and Technology, Yueyang, China
Abstract: Reactive extraction is proposed as a promising approach to the resolution of tropic acid (TA), where hydroxyethyl-β-cyclodextrin (HE-β-CD) is used as a selective extractant. The reaction between tropic acid and extractant occurred in the aqueous phase, and kinetic studies of reactive extraction have been investigated in a Lewis-type stirred cell. The batch experiments have been performed to study the process parameters affecting the extraction rate including agitation speed, interfacial area, pH value of aqueous phase, initial concentration of tropic acid enantiomers and initial concentration of extractant on the initial extraction rate. The kinetic equation of the forward rate was deduced at the experiment condition: r TA+ = (4.041 × 10−3)[TA+][CD]2; r TA− = (3.1234 × 10−3)[TA−][CD]2.
Keywords: Liquid–liquid extraction ; Kinetics ; Chiral resolution ; Tropic acid
Full paper is available at www.springerlink.com.
Chemical Papers 72 (3) 585–591 (2018)