ISSN print edition: 0366-6352
ISSN electronic edition: 1336-9075
Registr. No.: MK SR 9/7
Alkyl glycosides as potential anti-Candida albicans growth agents
Tomáš Klunda, Eva Machová, Alžbeta Čížová, Radim Horák, Monika Poláková, and Slavomír Bystrický
Institute of Chemistry, Slovak Academy of Sciences, Dúbravská cesta 9, 845 38 Bratislava, Slovakia
Abstract: Candida infections are becoming increasingly prevalent and many clinical isolates are resistant to common azole derivatives treatment. Accordingly, the capacity of a series of 19 alkyl glycosides, mainly mannosides and glucosides but also a cellobioside with aglycone chain-length from C-6 to C-20, to inhibit the growth of laboratory and clinically isolated strains of Candida albicans, was investigated. The study showed that only glycosides with the C-10 and C-12 aglycones were effective growth inhibitors of both types of Candida strains, whose metabolic activity was also significantly reduced as revealed by an XTT assay.
Keywords: susceptibility – synthetic glycosides – Candida albican
Full paper is available at www.springerlink.com.
Chemical Papers 70 (9) 1166–1170 (2016)