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Application of isotachophoretic and conductometric methods for neomycin trisulphate determination

Marzanna Kurzawa, Aneta Jastrzębska, and Edward Szłyk

Faculty of Chemistry, Nicolaus Copernicus University, 87-100 Toruń, 7 Gagarin str., Poland

 

E-mail: jmk@cc.uni.torun.pl

Received: 18 January 2008  Revised: 3 September 2008  Accepted: 4 September 2008

Abstract: Determination of neomycin trisulphate (NMS) in a dosage form (Neox and Neosol) was carried out by capillary isotachophoresis (cITP) with conductometric detection. The following electrolytes: leading: 10 mmol dm−3 sodium acetate + 0.08 % hydroxyethylcelulose (HEC) and acetic acid to pH = 5.5, and terminating: 10 mmol dm−3 β-alanine were tested for isotachophoretic separation of NMS. The calibration curve was linear over the range of 10.00 mg dm−3 to 100.00 mg dm−3 with LOD = 5.69 mg dm−3 and LOQ = 18.96 mg dm−3. The results were compared to the conductometric determination of NMS with: ammonium molybdate (VI), silver nitrate (V) and Reinecke salt. Good accuracy was obtained from conductometric titration of NMS with Reinecke salt, the recoveries being as follows: 100 % (RSD = 1.99 %); 96.17 % (RSD = 2.10 %) and 95.22 % (RSD = 1.55 %) for NMS in pure form, Neosol and Neox, respectively.

Keywords: capillary isotachophoresis - neomycin trisulphate - Neox - Neosol - conductometric titration

Full paper is available at www.springerlink.com.

DOI: 10.2478/s11696-008-0103-2

 

Chemical Papers 63 (3) 255–260 (2009)

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