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Benzothiazole compounds. XIII. Synthesis and antitubercular activity of some N-[1-(6-R-2-benzothiazolylamino)-2,2,2-trichloroethyl]formamide, -acetamide, -chloroacetamide, and -benzamide derivatives

S. Mikulášek, Ž. Odlerová, V. Sutoris, A. Perjéssy, and E. Solčániová

Department of Organic Chemistry, Faculty of Natural Sciences, Komenský University, 816 31 Bratislava

 

Abstract:  The preparation of N-[1-(6-R-2-benzothiazolylamino)-2,2,2-trichIoroethyljformamides, -acetamides, -chloroacetamides, and -benzamides from the original N-(1,2,2,2-tetrachloroethyl)amides and 2-amino-6-R-benzothiazoles (R = C1, Br, N02 , SCN, CH3) is described. Their structures were proved by 1H-n.m.r. spectra. When tested for antitubercular activity, the best results were obtained against the representatives of both the typical and atypical mycobac­teria. With some compounds also the acute toxicity was investigated.

Full paper in Portable Document Format: 325a691.pdf

 

Chemical Papers 32 (5) 691–700 (1978)

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