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Synthesis and antimicrobial activity of quinoline-based 2-pyrazolines

Munawar A. Munawar, Muhammad Azad, Makshoof Athar, and Paul W. Groundwater

Institute of Chemistry, University of the Punjab, 54590 Lahore, Pakistan

 

E-mail: munawaralimunawar@yahoo.com

Received: 5 April 2007  Revised: 25 September 2007  Accepted: 15 November 2007

Abstract: A series of 2-pyrazolines was prepared in a reaction of quinolinylchalcones with phenyl hydrazine under both conventional and microwave-induced heating. Structures of the synthesized compounds were characterized by spectroscopic data and CHN analyses. All prepared compounds were tested for antimicrobial activity against bacterial strains, viz. Staphylococcus aureus, Salmonella typhii, Escherichia coli, and Shigella dysentery. Almost all synthesized compounds have shown antimicrobial activity; however, compounds with a chloro group as a substituent have been found to be more effective.

Keywords: pyrazolines - chalcones -  N-substituted 3-acetyl-4-hydroxyquinolin-2(1H)-one - antimicrobial activity

Full paper is available at www.springerlink.com.

DOI: 10.2478/s11696-008-0025-z

 

Chemical Papers 62 (3) 288–293 (2008)

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