ISSN print edition: 0366-6352
ISSN electronic edition: 1336-9075
Registr. No.: MK SR 9/7
Benzothiazole compounds. XIV. Synthesis and antitubercular activity of some derivatives of N-[1-(4-R-2-benzothiazolyl-X)-2,2,2-trichloroethyl]- and N-[1-(2-X-6-R-3-benzothiazolinyl-Y)-2,2,2-trichloroethyl]formamides, -acetamides, -chloroacetamides, and -benzamides
S. Mikulášek, V. Sutoris, Ž. Odlerová, A. Perjéssy, and V. Konečný
Department of Organic Chemistry, Faculty of Natural Sciences,
Komenský University, 816 31 Bratislava
Abstract: N-[ 1 -(4-R-2-Benzothiazolyl-X)-2,2,2-trichloroethyl]formamide, -acetamide, -chloroacetamide, and -benzamide (R = H, CI; X = 0 , SCH2 CH20) and N-[l-(2-X-6-R-3-benzothiazolinyl-Y)-2,2,2-trichloroethyl]f ormamides, -acetamide, -chloroacetamides, and -benzamide (R = H, NH2 , N02; X = O, S; Y = —, CH2CH20) were prepared by treatment of 2-mercaptobenzothiazole and some of its derivatives with N-(l,2,2,2-tetrachloroethyl)amides.
Their structures were proved by interpretation of the i.r. spectra and structural
changes of some compounds submitted to pyrolysis were investigated. The
synthesized compounds were tested for antitubercular activity.
Full paper in Portable Document Format: 334a550.pdf
Chemical Papers 33 (4) 550–557 (1979)