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Preparation and properties of dialkylaminoethoxyazachalcones

A. Brádlerová, J. Ďurinda, and E. Mišíková

Department of Inorganic and Organic Chemistry, Faculty of Pharmacy, Komenský University, CS-832 32 Bratislava

 

Abstract:  Twenty 2-, 3-, and 4-(2-dialkylaminoethoxy)azachalcones have been syn­thesized by alkylation of hydroxyazachalcone, prepared in advance, or by Claisen—Schmidt condensation of dialkylaminoethoxybenzaldehydes with methyl pyridyl ketone. Ultraviolet, infrared, and 1H-n.m.r. spectra were used to verify the identity of the prepared compounds and establish the geometrical isomerism and conformations. Preliminary tests for antimicrobial activity and acute toxicity have been carried out with some of the azachalcones prepared.

Full paper in Portable Document Format: 372a251.pdf

 

Chemical Papers 37 (2) 251–262 (1983)

Monday, July 26, 2021

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