ISSN print edition: 0366-6352
ISSN electronic edition: 1336-9075
Registr. No.: MK SR 9/7
An efficient method for the preparation of benzyl γ-ketohexanoates
Muhammad Iqbal, Imam B. Baloch, and Musa K. Baloch
Department of Chemistry, Gomal University, 29050, Dera Ismail Khan, Pakistan
Abstract: Twenty acid chlorides, 4-(mono/di-benzyloxy)-4-ketobutanoyl chlorides (Ia–XXa) were synthesised by the reaction of monoesters of succinic acid with thionyl chloride. The product thus obtained (4-benzyloxy-4-ketobutanoyl chlorides) was treated with diethylcadmium to convert it into the corresponding keto-esters (Ib–XXb), the mono/di-benzyl-γ-ketohexanoates, with a good yield. All the compounds thus prepared were characterised by physical, spectroscopic (UV-VIS, IR, 1H NMR, 13C NMR), and mass measurements techniques.
Keywords: γ-ketoesters – mono/disubstituted-benzyl alcohols – diethylcadmium – monoesters of succinic acid
Full paper is available at www.springerlink.com.
Chemical Papers 67 (4) 444–455 (2013)
Sunday, September 27, 2020