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1,3-Dipolar cycloadditions of heterocycles. 22. Synthesis and biological activity of condensed isoxazolines

M. Konopíková, Ľ. Fišera, E. Šturdík, R. Ujhélyová, Š. Varkonda, and O. Hýblová

Department of Organic Chemistry. Faculty of Chemical Technology, Slovak Technical University, CS-81237 Bratislava

 

Abstract: The synthesis of condensed isoxazolines, containing an N-arylmaleinimide and an isoxazoline skeleton in the molecule is described. Thus the substituted 3, 5-diaryl-4, 6-dioxo-3a, 4, 6, 6a-tetrahydropyrrolo[3,4-d]-isoxazoles were synthesized by a 1, 3-dipolar cycloaddition of substituted benzonitrile oxides to substituted phenylmaleinimides, in which the substituent was H, Cl, F, Br, NO2, OCH3, CH3, CH(CH3)2, CF3, respectively. The prepared condensed isoxazolines were active against yeasts, moulds, and bacteria.

Full paper in Portable Document Format: 456a775.pdf

 

Chemical Papers 45 (6) 775–787 (1991)

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