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Spectrophotometric Analysis of α- and β-Naphthol Mixtures Applying Partial Least-Squares Method

A. L. Revilla, G. Vargas, and J. Havel

Department of Analytical Chemistry, Faculty of Science, Masaryk University, CZ-611 31 Brno, Czech Republic

 

E-mail: havel@chemi.muni

Abstract: Pharmaceutical and other chemical industries often require high purity of α-naphthol (αN) because it is used like a precursor for further synthesis. The determination of β-naphthol (βN) in mixture with  αN by spectrophotometry applying partial least-squares procedure was developed. Using the partial least-squares calibration, a model based on calibration measurement was developed and, afterwards, used to predict the test set (samples). Normal or derivative spectra in λ-ranges a) 190-250 nm or b) 260-345 nm were used. The method is suitable for fast determination of βN in mixtures with αN with relative standard deviation around 2 % for βN (if the content is higher than 1.5-3.0 %). Both studied λ-ranges can be used for the determination, but derivative spectra are advantageous for the 190-250 nm region.

Full paper in Portable Document Format: 531a34.pdf

 

Chemical Papers 53 (1) 34–39 (1999)

Wednesday, December 02, 2020

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