ISSN print edition: 0366-6352
ISSN electronic edition: 1336-9075
Registr. No.: MK SR 9/7

Published monthly
 

Nonbiodegradable Hyaluronan Derivative Prepared by Reaction with a Water-Soluble Carbodiimide

S. Bystrický, J. Alföldi, E. Machová, B. Steiner, and L. Šoltés

Institute of Chemistry, Slovak Academy of Sciences, SK-842 38 Bratislava

 

Abstract: Reaction of hyaluronan (HA) with 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) yielded a water-soluble polysaccharide with 40 % of modified HA carboxyl groups. 1H and 13C NMR measurements revealed that hyaluronan contained EDC bound by a nonspecific acylurea-type linkage. A test with testicular hyaluronidase showed that the modified hyyaluronan was resistant to enzymic degradation.

Full paper in Portable Document Format: 551a49.pdf

 

Chemical Papers 55 (1) 49–52 (2001)

Monday, January 18, 2021

IMPACT FACTOR 2019
1.680
SCImago Journal Rank 2019
0.331
SEARCH
Advanced
VOLUMES
XXVIII. International Conference on Coordination and Bioinorganic Chemistry
© 2021 Chemical Papers