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Nonbiodegradable Hyaluronan Derivative Prepared by Reaction with a Water-Soluble Carbodiimide

S. Bystrický, J. Alföldi, E. Machová, B. Steiner, and L. Šoltés

Institute of Chemistry, Slovak Academy of Sciences, SK-842 38 Bratislava

 

Abstract: Reaction of hyaluronan (HA) with 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) yielded a water-soluble polysaccharide with 40 % of modified HA carboxyl groups. 1H and 13C NMR measurements revealed that hyaluronan contained EDC bound by a nonspecific acylurea-type linkage. A test with testicular hyaluronidase showed that the modified hyyaluronan was resistant to enzymic degradation.

Full paper in Portable Document Format: 551a49.pdf

 

Chemical Papers 55 (1) 49–52 (2001)

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