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Protective effects of vitamin E against CCl4-induced hepatotoxicity in rabbits

K. Pawłowska-Góral, M. Wardas, P. Wardas, and A. Rzepecka-Stojko

Department of Food and Nutrition, Medical University of Silesia, Jagiellonska 4, 41-200 Sosnowiec, Poland

 

E-mail: katarzynagor@wp.pl

Received: 18 March 2006  Revised: 30 June 2006  Accepted: 31 July 2006

Abstract: The influence of CCl4 on the activity of superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR), the value of the total antioxidant status (TAS), and the concentration of malonic dialdehyde (MDA) and glutathione (GSH) was monitored in plasma or whole blood of rabbits. The administration of CCl4 caused the increase of the SOD activity to approximately 150 % and the decrease in the activity of GPx and GR by about 50 %. These changes were accompanied with the increase in TAS value and MDA concentration and the decrease of GSH concentration. The effect of CCl4 was suppressed by the previous 7 days lasting or simultaneous administration of vitamin E. Oxidative stress caused by CCl4 was accompanied by the development of reactive oxygen forms, especially superoxide radical anion.

Keywords: antioxidant enzymes - glutathione - total antioxidant status - malonic dialdehyde - vitamin E

Full paper is available at www.springerlink.com.

DOI: 10.2478/s11696-006-0087-8

 

Chemical Papers 61 (1) 6–10 (2007)

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