ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Rapid synthesis of pyrimidine derivatives using a reproducible catalyst based on triflate anion

Ebraheem Abdu Musad Saleh, M. M. Moharam, Fadhel F. Seed, R. Roopashree, Subhashree Ray, Karthikeyan Jayabalan, Renu Sharma, Aashna Sinha, I. B. Sapaev, and Devendra Pratap Rao

Department of Chemistry, College of Science and Humanities in Al-Kharj, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia

E-mail: e.saleh@psau.edu.sa

Received: 24 July 2025  Accepted: 14 November 2025

Abstract:

This research presents how to synthesize and characterize the 4,4’,4’’-(2,4,6-trimethyl-1,3,5-benzenetriyl)tris-pyridinium sulfonic acid tri-triflate (TMBTPST) salt as a novel and eco-friendly catalyst for the synthesis of pyrido[2,3-d:6,5-d′]dipyrimidines, and pyrido[2,3-d]pyrimidines. TMBTPST was characterized by various physicochemical methods. The results showed that this repeatable salt is capable of rapidly producing pyridine derivatives in excellent yields under environmental conditions consistent with green chemistry criteria (4a-4n: 89 to 98%, 4 to 10 min, and 7a-7 L: 88 to 98%, 5 to 13 min). These conditions were achieved through the use of a safe aqueous medium, the non-metallic nature of catalyst, mild temperature conditions (25 to 50 °C), and the synthesis of the products via a clean one-pot multicomponent approach without the generation of by-products.

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Keywords: Pyrimidine derivatives; Multicomponent reactions; Recyclable catalyst; Mild conditions

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-025-04516-4

Chemical Papers 80 (3) 2293–2306 (2026)