ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Alginate–zein composite modified with metal organic framework for sulfasalazine delivery

Tannaz Asadollahi, Negar Moatakef Kazemi, and Sara Halajian

Department of Nanochemistry, Faculty of Pharmaceutical Chemistry, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran

E-mail: motakef@iaups.ac.ir

Received: 24 June 2023  Accepted: 24 September 2023

Abstract:

Metal–organic frameworks (MOFs) have promising prospects as drug nanocarriers but are more limited in biomedical applications due to their poor stability and biocompatibility. To address this issue, sodium alginate–zein (SA-ZN) nanocomposites modified metal–organic framework were developed and used as an effective nanocarrier for sulfasalazine (SSZ) delivery and reduced side effects of, thus improving its bioavailability SSZ. The obtained nanocomposite was structurally and morphologically characterized using different physicochemical techniques including Fourier transform infrared (FTIR), X-ray diffraction (XRD), and field-emission scanning electron microscopy (FESEM). Based on the results, the Zn₂(BDC)₂(DABCO) MOFs were dispersed in biopolymers. In addition, the antibacterial properties of samples have been studied against Staphylococcus aureus and Pseudomonas aeruginosa. The results showed that the drug-loaded MOF/SA-ZN has a higher antibacterial activity against S. aureus gram-positive bacteria compared to SSZ. The current research provides a promising insight into the fabrication of polymer-modified MOF-based drug delivery platforms and antibacterial agents.

Keywords: Alginate; Antibacterial; Metal–organic framework; Sulfasalazine; Zein

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-023-03110-w

Chemical Papers 78 (1) 565–575 (2024)