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Investigation of the impacts of simple electrolytes and hydrotrope on the interaction of ceftriaxone sodium with cetylpyridinium chloride at numerous study temperatures

Md. Nazrul Islam, Malik Abdul Rub, Maha Moteb Alotaibi, Md. Tuhinur R. Joy, Israt Jahan, Shamim Mahbub, Shahed Rana, Dileep Kumar, M. Alfakeer, Abdullah M. Asiri, Md. Anamul Hoque, and Shariff E. Kabir

Department of Chemistry, Jahangirnagar University, Savar, Dhaka, Bangladesh

 

E-mail: kumar.dileep@vlu.edu.vn

Received: 28 January 2023  Accepted: 3 May 2023

Abstract:

Herein, interactions between cetylpyridinium chloride (CPC) and ceftriaxone sodium (CTS) were investigated applying conductivity technique. Impacts of the nature of additives (e.g. electrolytes or hydrotrope (HDT)), change of temperatures (from 298.15 to 323.15 K), and concentration variation of CTS/additives were assessed on the micellization of CPC + CTS mixture. The conductometric analysis of critical micelle concentration (CMC) with respect to the concentration reveals that the CMC values were increased with the increase in CTS concentration. In terms of using different mediums, CMC did not differ much with the increase in electrolyte salt (NaCl, Na2SO4) concentration, but increased significantly with the rise of HDT (NaBenz) amount. In the presence of electrolyte, CMC showed a gentle increment with temperature, while the HDT showed the opposite trend. Obtained result was further correlated with conventional thermodynamic relationship, where standard Gibb’s free energy change \((\Delta G_{m}^{o} )\), change of enthalpy \((\Delta H_{m}^{o} )\), and change of entropy \((\Delta S_{m}^{o}\)) were utilized to investigate. The \(\Delta G_{m}^{o}\) values were negative for all the mixed systems studied indicating that the micellization process was spontaneous. Finally, the stability of micellization was studied by estimating the intrinsic enthalpy gain (\(\Delta H_{m}^{o,*}\)) and compensation temperature (Tc). Here, CPC + CTS mixed system showed more stability in Na2SO4 medium than the NaCl, while in NaBenz exhibited the lowest stability.

Keywords: Surfactant system; Molecular assembly; Hydrotrope; Thermodynamics; Interaction forces

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-023-02856-7

 

Chemical Papers 77 (9) 5199–5212 (2023)

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