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Numerical simulation of blood cell separation in an acoustofluidic system

Nava Zarkhah, Saba Samankan, Mehdi Mehrpooya, and Reza Askari Moghaddam

Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran

 

E-mail: mehrpoya@ut.ac.ir

Received: 13 May 2022  Accepted: 26 June 2022

Abstract:

For the last two decades, acoustofluidic systems, among other techniques, have drawn considerable attention due to their biocompatibility. A number of experimental works have been performed in this area, but the need for numerical analysis to decrease the manufacturing costs has persuaded many researchers to work in this field in the last few years. In this study, a numerical approach has been developed to investigate the influence of different parameters on the separation process of blood cells, WBCs, RBC and platelets, in microfluidic system, containing three inlets (one for buffer fluid and two side inlets for blood cells) and five outlets. Effect of input voltage, fluid velocity and the distance of IDTs from the channel has been studied. It was observed that increasing the voltage increases the acoustic pressure amplitude, linearly. It was also found that changing the velocity of each of the inlets has a different impact on the separation process. The distance of IDTs from the channel inversely impacts the separation of cells.

Keywords: Cell separation; Acoustofluidic system; Numerical analysis

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-022-02349-z

 

Chemical Papers 76 (11) 6683–6698 (2022)

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