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Two Co(II) coordination polymers: application values on spinal osteomyelitis by reducing the inflammatory response in the paravertebral soft tissue

Da-Peng Fu, Sheng Yang, Jian-Min Lu, Hao-Yi Lian, and Kai-Rong Qin

Department of Orthopaedics, Affiliated Zhongshan Hospital of Dalian University, Dalian, China

 

E-mail: Fudapeng2020@163.com

Received: 13 October 2020  Accepted: 19 November 2020

Abstract:

In the present research, two novel coordination polymers (CPs) containing Co(II) ions as nodes have been prepared by solvent thermal reaction between free organic ligands of HL and Co(NO3)2·6H2O in distinct solvent systems, and their chemical formulae are [Co(L)2]·CH3CN (1, (HL = 6-aminonicotinic acid) and [Co(L)2] (2). Their treatment activity on the spinal osteomyelitis was assessed. Meanwhile, the specific mechanism was investigated. First, the inflammatory cytokines content released into the paravertebral soft tissue was detected through the enzyme-linked immunosorbent assay (ELISA) detection kit. In addition to this, the reactive oxygen species (ROS) levels in the paravertebral soft tissue were also determined with flow cytometry.

Keywords: Coordination polymer; Spinal osteomyelitis; Paravertebral soft tissue

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-020-01442-5

 

Chemical Papers 75 (5) 2217–2224 (2021)

Sunday, June 20, 2021

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