Solution combustion method for synthesis of ZnO NPs from Syzygium hemisphericum bark extract and a comparative analysis of the same with the crude bark extract for biomedical applicationsC. H. Sushmitha, G. Krishnakumar, and K. Meghana Navada Department of Applied Botany, Mangalore University, Mangalagangothri, India
E-mail: kkgtaxo13@gmail.com Received: 23 August 2023 Accepted: 10 January 2024 Abstract: This study is aimed at the bio-fabrication of zinc oxide nanoparticles (SHB@ZnO NPs) from the aqueous bark extract of Syzygium hemisphericum (SHBW) and their comparative analysis for biomedical applications. The FT-IR spectra reveal the Zn–O bond by the appearance of peaks at 411 cm−1 and 398 cm−1. Further, the peak at 370 nm in UV–Vis spectra analysis affirms the same. The X-ray diffraction reveals the ultrafine structure of NPs (10 nm). The morphology of the NPs depends on fuel load as analyzed from FESEM images. A prodigious antioxidant activity of SHBW was observed compared to ZnO NPs with IC50 values of 8.877 ± 0.14 µg/mL and 236.74 ± 2.55 µg/mL, respectively. SHBW showed a markable α-amylase (37.68 ± 2.33 µg/mL) and α-glucosidase (37.68 ± 2.33 µg/mL) inhibitory activity compared to the SHB@ZnO-20. The antibacterial activity of synthesized NPs was observed against a wide range of strains. The HRBC membrane stabilization assay was carried out to substantiate the non-toxic nature toward human RBC’s (71.30% for SHBW and 46.96% for SHB@ZnO-20). The anticancer activity of ZnO NPs utilizing a definite volume of reducing agent was analyzed against A431 cancer cell lines which revealed that the cell viability decreased as NPs concentration (64.80% at 50 µg/mL) increased. Graphical abstract Keywords: Syzygium hemisphericum; ZnO nanostructures; Skin cancer suppressor; Antidiabetic; Antibacterial; GC–MS Full paper is available at www.springerlink.com. DOI: 10.1007/s11696-024-03319-3
Chemical Papers 78 (6) 3443–3462 (2024) |
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